The Nmda Receptor Supramolecular Complex

to localize protein kinases such as CaMKII postsynaptically.

However, the ERK, PKA, and src cascades in other cellular domains may achieve effects more broadly, and indeed be subject to additional mechanisms of regulation. This has been demonstrated in studies investigating ERK signaling to the nucleus. At a minimum, it appears that there are at least two (likely more) functional pools of ERK and PKA in neurons—one involved in local regulation of the dendritic spine compartment and a second involved in regulating gene expression.

Table 3 Components of the Synaptic Infrastructure Necessary for NMDA Receptor Function




Cell adhesion molecules

Mind and Memory Mastery

Mind and Memory Mastery

Tap into the memory secrets of geniuses… Discover The Untold Mind And Memory Secrets Used By The World’s Smartest People To Help You Unleash Your Full Potential! Finally You Can Fully Equip Yourself With These “Must Have” Mind And Memory Tools For Creating Your Ideal Lifestyle! Let’s face it, We all know the fact that we aren't using more than 10% of our brains. If we could, we'd be achieving much more and giving our fullest gifts to the world.

Get My Free Ebook

Post a comment