The Nmda Receptor Supramolecular Complex

to localize protein kinases such as CaMKII postsynaptically.

However, the ERK, PKA, and src cascades in other cellular domains may achieve effects more broadly, and indeed be subject to additional mechanisms of regulation. This has been demonstrated in studies investigating ERK signaling to the nucleus. At a minimum, it appears that there are at least two (likely more) functional pools of ERK and PKA in neurons—one involved in local regulation of the dendritic spine compartment and a second involved in regulating gene expression.

Table 3 Components of the Synaptic Infrastructure Necessary for NMDA Receptor Function

Component

Targets

Role

Cell adhesion molecules

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