P

p53 tumor suppressor protein, 318, 324

Pain sensitization, 55b thresholds, 56b Paired Pulse Facilitation, 113-114b, 114f

Pairing LTP, 104-106, 105f back-propagating action potentials, 105-106, 105f coincidence detection, 104, 106f EPSPs, 105-106, 105f postsynaptic membrane depolarization, 104 run down of postsynaptic response, 104

Parallel fibers, 291-293b Passive avoidence, 33 performance deficits, 46 foot shock alone control, 49 tests of overall health, 53 Pavlov, Ivan, 17-18, 30 Pavlovian conditioning, see

Associative conditioning Paylor, Richard, 43-44b Perception of the environment, 68 Perforant path, 94, 93f, 96-97,97f Perirhinal Cortex, 63f, 63-64 Peroxynitrite, 204f Perpetual memory, 367 Persistence of memories, 385b Persisting biochemical signals,

181-182, 189-191, 191f Pharmacogenetics, 314 Philosophy, 272 Phosphatidylinositol 4,5-bis phosphate, 163b Phosphodiesterase, 163b Phospholipases, 210f Phospholipase A1, 210f Phospholipase A2 (PLA2), 96b, 210-211, 210f Phospholipase C (PLC), 95b, 162, 168, 168f, 210, 210f Phospholipase D, 210, 210f target for the calcium trigger, 192f, 210-211 Phospholipids, 194, 370, 210f Phototaxis, 15-16b PHOX proteins, 192f PI3 Kinase, 213-215b PICK-1, 173

PKA, 95b, 153, 153f, 162b, 173 CREB gene regulation system, 242

effectors in Aplysia presynaptic facilitation, 380-381b facilitation in Aplysia, 377-384 link to PI3 Kinase, 213-215b pathway inplicated in LTP, 200-201b protein phosphatases, 178-179, 178f PKG, 198, 244

PKM zeta, 209-210, 222, 222f Place cells, 36, 66-67

abstract representation, 68 aging-related decline, 338 continuous odor-guided non-matching to sample, 81-83,81-82f direction selectivity, 67f double rotation experiment, 80 experience-dependent changes in, 73f in vivo hippocampal recordings, 274

intent cells, 75 LTP, 286

mulimodal cells, 79 single "unit" recordings, 66, 66f texture and olfactory cells, 79 time-dependent changes in, 74 Polyribosomes, 222, 222f Population EPSP, 99 Population Spike, 100, 127, 131 Post-Synaptic Density (PSD), 142-144, 167-169 AMPAR, 217 CaMKII, 173, 196 complex, 172, 254 Post-tetanic potentiation, 87,

113-114b, 114f Post-traumatic stress disorder, 54b Potassium channels, 74 A-type currents, 155-157 H current, 159 PP1, 178-179, 178f, 207-208b, 209 PP2B, 173, 178, 178f Pre-pulse inhibition, 54-55, 56f Presenilins, 348 Presynaptic release machinery,

380-381b Prion proteins, 387 Prolyl cis-trans isomerization, 190 Proteasome, 318 Protein dephosphorylation, 179 Protein half-lives, 370, 379,

385-386, 388 Protein Kinase B, see AKT Protein kinase C (PKC), 95b AMPAR, 173, 215-216 autoinhibitory domain, 119b autonomously active, 252, 386 autophosphorylation in LTP, 205-208, 206f, 207-208b, 386

C2 domain, 193-194, 193f dendritic protein synthesis, 223, 222f dephosphorylation, 207-209,

207-208b effectors in Aplysia presynaptic facilitation, 380-381b E-LTP, 199-200

facilitation in Aplysia, 377-384 hinge region, 209 isoforms, 200, 202f LTD, 295b

LTP, 119-120b, 120f, 200-201b NMDAR, 152

oxidation, 204-205, 204f, 386 persistent activation, 203 PKCa, 203

PKCß, 202-203, 203f PKCß knockout mouse, 271 PKCy, 200, 203f PKCZ, 386

protected-site phosphorylation,

207-208b, 209 proteolytic activation, 209 second messenger, 163b target for the calcium trigger,

191-194, 192f, 198-210 zinc finger region, 204 Protein Phosphatases, 196, 205 Protein synthesis, consolidation of long-term memory, 290 E-LTP, 190-191 FMRP, 329 inhibitors, 10-11, 11f L-LTP, 234 RSK2, 315 Protein turnover, 254, 369-372, 371f

Proteolysis, 190, 218 PSD-95, 142-145, 152, 167-169, 172 Purkinje neurons, 291-293b Putrescine, 154

Pyramidal Neurons, 37, 63, 74, 77f,

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