Chapter Overview

The chapter will be broken down into three broad sections (see Figure 1). The first section will deal with two well-established targets of the triggering calcium for LTP— CaMKII and PKC. In this section, I will focus principally on the known mechanisms for generation of persistently activated forms of these kinases, forms of the molecules that are capable of serving as molecular memory traces in LTP and memory in

* = Persistently Activated

FIGURE 1 Chapter summary. This chapter deals with three primary issues related to mechanisms for E-LTP. First, describing mechanisms for generating and maintaining persisting signals at the synapse (1). Second, discussing molecular sites of action of these persisting signals that operate in the expression of E-LTP (2). Third, reviewing some of the mechanisms involved in the regulation of local dendritic protein synthesis and synaptic tagging, mechanisms involved in the E-LTP to L-LTP transition (3).

* = Persistently Activated

FIGURE 1 Chapter summary. This chapter deals with three primary issues related to mechanisms for E-LTP. First, describing mechanisms for generating and maintaining persisting signals at the synapse (1). Second, discussing molecular sites of action of these persisting signals that operate in the expression of E-LTP (2). Third, reviewing some of the mechanisms involved in the regulation of local dendritic protein synthesis and synaptic tagging, mechanisms involved in the E-LTP to L-LTP transition (3).

general. This, then, deals with E-LTP maintenance. The second section of the chapter will deal with potential effectors of the persistently activated kinases: postsynaptic glutamate receptors, the presynaptic release mechanism, and the cytoskeleton. This section deals with mechanisms of E-LTP expression. The final section deals with dendritic protein synthesis plus the idea that synaptic "tags" are generated in response to LTP-inducing stimulation. This is not a component of E-LTP per se, but rather is a mechanism likely to contribute to the E-LTP-to-L-LTP transition. It may be helpful to think of the generation of synaptic tags and the regulation of local protein synthesis as a parallel mechanism triggered by some of the events associated with E-LTP induction (or maintenance). These parallel mechanisms also entail an early and persisting signal but are basically a complex part of the initial stage of L-LTP induction.

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