Cerebellar Longterm Depression

Workers in the cerebellum might state that LTP does not equal memory because LTD equals memory. Specifically, LTD of synaptic connections in the cerebellar cortex has been demonstrated to play a role in two important forms of learned behavior: adaptation of the vestibulo-ocular reflex (VOR) and eye-blink conditioning (reviewed in references 10 and 58).

As we discussed in Chapter 2, classical conditioning of the eye-blink response in rabbits uses delivery of a neutral stimulus such as a tone paired with a mild aversive stimulus such as an airpuff delivered to the surface of the eye (Panel A). With repeated pairings, animals learn that the tone predicts the air-puff, and they will learn to "blink" when the tone is delivered by itself; a learned protective response involving co-opting a reflex pathway. Eye-blink conditioning sounds simple but is actually fairly complex. For example, the "blink" is really more than a blink; it is an elaborate programmed motor response involving a number of muscle groups that cause eyeball retraction and closure of the eyelid. The animals also can learn precisely the temporal relationship between tone and air-puff. They automatically adjust their "blink" to slightly precede when the air-puff would be

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