C

C/EBP (CCAAT Enhancer Binding

Protein), 239, 248, 290 Caboche, Jocelyn, 240 Cadherins, 255-256, 256f CAKbeta, 152, 153f Calcineurin, see PP2B Calcium, handling, 174-175 binding protein, 192-194, 192f, 193f calcium-induced calcium release, 176 chelators, 110-113 influx, 104, 380b

NMDA receptor-dependent LTP, 112-113

NMDAR as Calcium channel, 104

postsynaptic calcium, 110-113,

148, 174 signal, 192 Calcium/calmodulin-dependent Protein Kinase, see CaMKII Calcium-induced calcium release, 176

Calmodulin, 179-180, 180f binding, 180

E-F hand, 193, 193f, 194f, 195f, 197f potential targets of the Ca++ signal, 192-198, 192f, 193f, 194f, 195f, 197f Calpain, 192f, 203, 209-210, 218 CaMKII, 50, 50f, 95b activation of, 195f, 195-196 in Angelman syndrome, 316, 324 as temporal integrator, 197-198, 197f autonomously active, 252, 386 autophosphorylation, 196-198 in CREB gene regulation system, 242

in dendritic protein synthesis, 222

dephosphorylation of, 196 involved in human learning and memory, 308 in LTP induction, 119-120b, 183 in LTP maintenance, 197 pathway implicated in LTP, 200-201b phosphorylation of AMPAR,

215-216 in PLC/PKC/neurogranin system, 179-180 stabilizes AMPA receptors, 217 in synaptic infrastructure,

173-174 target for the calcium trigger, 192-198, 192f, 193f, 194f, 195f, 197f Thr286, 196, 324 Thr305/306, 197, 324 time courses in LTP associated molecular changes, 283-284 translocation to the PSD, 196-197

CaMKIV, 192f, 236f, 237, 242-244, 295b cAMP gate, 177-180, 178f, 181f, 198 cAMP-dependent protein kinase

(PKA), see PKA Cancer research, 316

Carcinogenesis, 387 Carew, Tom, 373 Casein Kinase II (CKII), 154 Castellucci, Vince, 13, 321b, 373 Catenins, 256f

CCAAT Enhancer Binding Protein, see C/EBP CDK-5, 153, 153f, 165, 165f CDKs, 152, 153f Cell division, 315 Cell surface adhesion molecules,

163-167 Central pattern generators,

374-376b Cerebellum, 17, 25

cerebral cortex, 294, 296f, 297 LTD, 291-293b Chen, Shu-Jen, 180 Chetkovich, Dane, 175 Chiba, Andrea, 75 Chloride channels, 95b Cholinergic hypothesis of AD,

343-344b Classical conditioning, see associative conditioning Cline, Holly, 195 Clinton, Bill, 235 c-Myc, 245

Coffin-Lowry syndrome, 309,

314-316 Cognition, 62, 65, 68

deficits in mental retardation,

307-308, 333 patient H.M., 85-86, 86f Cohen, Neal J., 8, 25, 37 Coincidence detection, 148,

180-183, 182f, 288 Colbert, Costa, 160 Collingridge, Graham, 102, 169b Complexities of LTP, 116 Conditioned food aversion, 9 Conditioned response, 17-18, 18f, 26-27

Conditioned stimulus, 17-18, 18f, 26-27

Conditioned taste aversion, 21-23, 22f, 41-42, 42f latent inhibition, 41 long CS-US interval in, 22 novel taste in, 22, 41 novelty detector, 41-42 poisonous foods in, 22, 41 toxic agent in, 22 Conscious learning, 6,7 Conscious recall, 20 Consolidation, 10, 11f, 61-62, 83-86 long-term memory, 290, 294-298 reconsolidation, 84b, 11-12 role of LTP, 264, 296f sleep for memory consolidation, 71-72b Continuous odor-guided non-matching to sample, 81-83, 81-82f Cortex, 63f, 63, 64, 93f, 294 CPEB, 253

Craigen, William, 176-177 Crawley, Jaqueline, 43-44b CRE, 239, 241, 241f CREB

activation of, 290

in facilitation in Aplysia, 377-384

gene regulation system, 241-243,

241-243f in induction of L-LTP, 237, 240 involved in Coffin-Lowry syndrome, 314 link to PI3 Kinase, 213-215b phosphorylation, 242-244 ser133, 241, 241f CREB Binding Protein (CBP), 242,

244, 315b Crick, Francis, 386 Crow, Terry, 15-16b Current clamp experiments, 98b Cyclic AMP, 95b, 157-159b Cyclic AMP Response Element

(CRE), 48, 49f Cyclic GMP-dependent Protein

Kinase (PKG), see PKG Cyclic nucleotides, 159 Cyclo-oxygenase pathway, 211 Cyclosporin A, 177 Cytoplasmic Polyadenylation Element Binding Protein, see CPEB Cytoskeleton, 163, 217-218, 256

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