A

a7 nicotinic ACh receptor,

343-345b Abraham, Cliff, 223 Acetylcholine receptor, 183 Acetylation, 190 Acetylcholine, 64, 94, 136-138b Acetylcholinesterase, 343b Acoustic startle, 54-55, 56f Actin Depolymerization

Factor(ADF)/cofilin, 328b Actin matrix, 164-167 Actin turnover, 329b, 370, 371f Actinomycin D, 236 Action potential, 67, 74

see also Back-propagating action potential dendritic, 106-110, 124b increased firing during LTP,

127-130 propagation, 108-109 threshold, 381b Adams, Paige, 156 Adenylyl cyclase, 95b, 162 knockout mice, 198, 199f in PLC/PKC/neurogranin system, 179-180 regulated by NF1, 314 target of CaM, 198 AC I/VIII, 242 ADP-ribosylation, 190 Aging-related memory decline,

40-41, 41f, 54b, 338-339 AKAP79, 173 AKT, 213-215b Alberini, Cristina, 248 Alkon, Dan, 15-16b

Allodynia, 55b Alzheimer, Alois, 341b Alzheimer's Disease, 336 Alzheimer's Disease, 317b, 337-360 Aß42 as the cause of AD, 349-350

aging-related memory decline,

338-339 ApoE4 Alleles, 354-355 Apolipoprotein E, 355 APP mutations, 352 diagnosis, 340, 341-342b familial and late-onset AD, 352 genes involved, 339 immunotherapy, 350-351b memory disorder, 340 mouse models, 355-360 nun study, 353b presenilin mutations, 354 stages, 339-340, 342 symptoms, 342-343, 345 neurofibrillary tangles, 346 amyloid plaques, 346-349 Amino Acids, 190 Amnesia, 24 AMPA receptor, 95b activation, 125-127b, 126f in E-LTP, 212-216 function, 160-161 GluR1, 239 half-life, 172, 369 insertion, 124b, 216, 217f, 256 internalization, 295b in L-LTP

gene target, 250 component of structural change, 254

phosphorylation, 139-141b, 141f, 161, 213, 215-216 by CaMKII or PKC, 215-216 Ser831, 215-217 regulation, 216-218, 217f silent synapses, 122, 123-124,

123f stabilized by autophosphorylated CaMKII, 217 structural component of the synapse, 172-173 structure, 215-216 trafficking, 216-217 Amygdala, 25

LTP and memory linked in,

275-278b pairing LTP in, 143b, 143f patient H.M., 84-86,86f PKCp in, 271 principal circuit, 276b role in reconsolidation, 84b Amyloid beta, 337, 345b, 346-351 AP42, 346

Ap peptide immunization,

350-351b structure, 346, 347f Amyloid plaque, 345, 345f Amyloid precursor protein (APP), 317b

Anderson, Anne, 157 Anderson, Per, 96 Angelman Syndrome, 308-309, 316-321, 323-325 E6-AP ubiquitin lgase, 316, 318 developmental derangements, 316

Angelman Syndrome (continued) imprinting, 318 role of CaMKII, 324 symptoms of, 316 ube3a knockout mice, 319, 319f Anxiety, 53, 54f Aplysia californica, CREB regulation, 248 defensive withdrawal reflex of,

11f, 14 habitat, 14-15b habituation, 12 inking response, 14-15b intermediate-term facilitation,

378-379 long-term facilitation, 379,

382-384 model system, 13-16 protein phosphorylation, 369 sensitization, 11f, 14, 322b, 373, 377

short-term facilitation, 377-378, 378f ubiquitin system, 321-323b ApoER2, 355

Apolipoprotein E, 152, 153f, 35 Apolipoprotein E Receptor 2, see ApoER2 Arachidonic Acid, 210-211, 210f modifed by lipoxygenase pathway, 211 modified by cyclo-oxygenase pathway, 211 PLA2 liberates free AA, 96b Arc/Arg3.1, 69-71b, 222, 225, 238-239, 245, 250, 252f, 253, 290 Area CA1, 99, 111-112 Area CA3, 112, 220 ARHGEF6, 330b Arrhenius Equation, 133-134 Ashe, Karen Hsiao, 356, 359 Associative conditioning, see also associative learning, cause and effect relationship,

18-19, 25 comparison to pairing LTP, 105 conditioned response, 17-18, 18f, 26-27

conditioned stimulus, 17-18, 18f, 26-28

contingency, 19, 27,81-83 contiguity, 19 examples, 21-25, 34 see also fear conditioning hermissenda, 15-16b molecular changes, 26 Pavlov and, 17-18, 17f salivatory response, 17, 18f types, 19-20, 19f unconditioned response, 17-18,

18f, 26-27 unconditioned stimulus, 17-18, 18f, 26-28 Associative learning, 7f,8f, 18-20 attributes of, 19, 22-23 backward pairing of CS and US, 26

cue learning, 31-33 distal cues, 78-80, 79-80f error-proneness in, 19 inaccurate memory during, 19 Macaque monkeys, 18-21 mechanisms contributing to, 183 pigeons, 19-21 role for LTP in, 286 superstitious behaviors in, 19 Associativity, 105-106 Atkins, Coleen, 50, 98, 279 Autonomous Kinases in the PSD, 188 Avoidance Conditioning, active avoidance, 34f, 35 passive avoidance, 33-35, 34f, 35f as control for cued FC, 33 step-down method, 34f, 35 step-through method, 34f, 35

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