70

TABLE BOX 4 Summary of molecular composition of the NMDAR supramolecular complex. The component molecule and its molecular weight are list. Adapted from Husi et al. (90).

Hebbosome is even bigger than the huge molecular complex already described. In fact, the Hebbosome may be the entire postsynaptic spine compartment. Even this idea leaves out presynaptic factors.

Consideration of the NMDA receptor supramolecular complex raises an additional important point to bear in mind. Briefly stated, Figures 2-4 are inadequate in a structural sense. As illustrated in these figures, signaling by the various protein kinase cascades is greatly influenced by scaffolding proteins that serve to localize the signal transduction machinery to appropriate subcellular compartments. However, it is useful to also think of "signaling compartments" within neurons. A given molecular cascade in some locales within the cell will be constricted in its range of effects and effectors, achieving effects locally. The NMDA receptor supramolecular complex including NF1, ras/ERK, and the like is likely to function in this manner. The NMDA receptor complex also serves

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