Types and Dosage of Estrogen

There are different types of estrogen in the blood and in the brain—estriol and estradiol, for example—but they are all fairly similar in their actions. For postmenopausal women, estrogen ranks high on my list of medications to prevent age-related memory loss, and as a potential treatment for mild memory loss. If you have had a hysterectomy, the simplest therapeutic approach is to take conjugated estrogen, which is marketed as Premarin. The standard Premarin dose is a single tablet of 0.625 mg daily. If you have not had a hysterectomy, it is necessary to add progesterone, which is the other main female hormone. Combining the two reduces the risk of cancer of the uterus. You can achieve this by taking a single daily tablet of an estrogen-progesterone combination that contains 0.625 mg Premarin and 2.5 mg medroxyprogesterone acetate. There are over a dozen brands of estrogen-progesterone combinations on the market, but they are all about the same. They are all prescription medications, and you need to work out the exact doses, as well as the timing sequence of estrogen and progesterone therapy, with your doctor (internist or gynecologist).

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