Psychotherapy can be useful in the treatment of milder forms of depression. Cognitive-behavioral and interpersonal psychotherapy, which require the therapist to be very active compared to traditional psychoanalysis, have been shown to be effective in the treatment of mild to moderate depressive illness. Highly motivated patients show the greatest benefit from these forms of therapy— for example, cognitive therapy requires patients to do homework exercises to help correct their negative, distorted attitudes about themselves and other people. A recent pharmaceutical industry-supported study by Keller and his colleagues suggested a synergistic effect from combining the antidepressant nefazodone (Serzone) and cognitive-behavioral psychotherapy, but these results are not consistent with the prior literature on combining antidepressant medications and psychotherapy.

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