Choline

Choline is directly converted into acetylcholine by combining with acetic acid, and you might think that choline should work quite well as a memory enhancer. Unfortunately, although animal studies show that choline heightens attention and helps to transfer information from short to long-term memory, the clinical data are inconsistent and unimpressive. Several placebo-controlled trials to treat Alzheimer's disease have met with failure. Similar efforts with choline have not worked in people with mild to moderate memory loss. To produce even the slightest effect, choline needs to be ingested in huge quantities of 3 to 12 grams daily. Another practical problem is that if you take this substance, you may exude a fishy smell, not a very appetizing prospect for bystanders, let alone your loved ones.

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